IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

ALEFACEPT - INTRAMUSCULAR

(al-EF-ah-sept)

COMMON BRAND NAME(S): Amevive

USES: This medication is used to treat moderate to severe chronic plaque psoriasis.

HOW TO USE: Use this medication exactly as prescribed. This drug is given by intramuscular injection (IM) by a healthcare professional once weekly. All the preparation and administration instructions in the product package should be followed. Ask your doctor or pharmacist if you are unclear on any information. Rotate injection sites. New injections should be given at least one inch from an old site. Do not inject into areas of the skin that are sore, bruised, red or hard. To prevent foaming of the medication, the bottle should not be shaken when the dose is prepared. Do not use if the liquid contains particles or is discolored or cloudy. Make sure needles and any medical supplies are stored safely and disposed of properly. Use this medication regularly in order to get the most benefit from it. To help you remember, take it on the same day each week.

SIDE EFFECTS: Pain, swelling, or bleeding at the injection site may occur. Dizziness, throat inflammation, increased cough, nausea, itching, muscle pain, or chills may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if this highly unlikely but very serious side effect occurs: chest pain. Though very unlikely, you may have a slightly increased risk of developing a cancer due to this medication. Tell your doctor immediately if you develop symptoms such as : unusual lumps, swollen glands, skin lesions/spots that are new or change appearance. Tell your doctor immediately if you develop signs of infection while using this drug, such as: fever, chills, persistent sore throat, trouble breathing, painful or frequent urination, unusual vaginal discharge, white patches in the mouth (oral thrush). An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of cancer, active infections, currently receiving phototherapy. Before using this medication, tell your doctor or pharmacist your medical history, especially of: recurrent infections (e.g., pneumonia, skin infections), immune system disorders (immunosupression), any allergies. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine. This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. This medication should not be used by children. Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Breast-feeding is not recommended while using this drug.

DRUG INTERACTIONS: Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: drugs that may suppress your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine), live vaccines. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: chills, headache, or joint pain.

NOTES: Do not share this medication with others. Laboratory and/or medical tests (e.g., T lymphocyte counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

STORAGE: Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Once prepared the diluted solution should be refrigerated and used within 4 hours. Check the expiration date on the label and properly discard any unused medication after that time. Do not store in the bathroom. Keep all medicines away from children and pets.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854- 1166 (USA) or 1-800-668-1507 (Canada).

Developed by First DataBank, Inc., San Bruno, CA
Copyright 2004 by First DataBank, Inc.