IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

AMINOPHYLLINE - INJECTION

(am-in-AWF-uh-lin)

USES: Aminophylline opens breathing passages in the lungs. It is used to treat breathing problems such as asthma, chronic bronchitis and emphysema.

HOW TO USE: Use this medication exactly as prescribed. This drug is given slowly by vein (IV), diluted in IV fluids as directed. Dosage is based on your condition and response to therapy as well as drug blood levels. Learn all preparation and administration instructions in the product package and ask your doctor or pharmacist if you are unclear on any information. A harmless yellowish discoloration may occur when this drug is mixed in dextrose. Do not use if the solution contains crystals/particles. Make sure needles and any medical supplies are stored safely and disposed of properly.

SIDE EFFECTS: Flushing, nausea, vomiting, diarrhea, loss of appetite, irritability, nervousness, trouble sleeping and increased urination may occur. If these effects persist or worsen, notify your doctor promptly. Unlikely but report promptly: stomach pain, coffee-ground vomit, dizziness/fainting, severe mental/mood changes, rapid breathing, irregular heartbeat (unusually fast or slow), chest pain, muscle twitching, seizures. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: swelling of the throat, rash, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, including: any allergies, seizure disorders, high blood pressure, diabetes, stomach/intestinal ulcer, eye disease (glaucoma), heart disease, liver or kidney disease, flu symptoms (e.g., high fever), other lung disease, thyroid disease. Avoid drinking large amounts of beverages containing caffeine (e.g., coffee, tea, cola). Smoking may affect this medication. Inform your physician if you are a smoker. Also consult your physician if you quit smoking. A dosage adjustment may be necessary. Caution is advised when using this in the elderly, as this group may experience more drug side effects. Caution is advised when using this in children, as this group may experience more drug side effects. A preservative (benzyl alcohol) which may be found in this product or in the liquid used to mix this product (diluent) can infrequently cause serious problems (sometimes death) if given by injection to an infant during the first months of life (neonatal period). The risk is greater with lower birth weight infants and is greater with increased amounts of benzyl alcohol. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat. Report these symptoms to the doctor immediately should they occur. If possible, a preservative-free product should be used when treating neonates. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: cimetidine, allopurinol, lithium, quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), macrolide antibiotics (e.g., clarithromycin, erythromycin), rifamycins (e.g., rifampin), birth control pills, carbamazepine, phenytoin, barbiturates (e.g., phenobarbital), beta-blockers (e.g., propranolol), "blood thinners" (e.g., warfarin), fluvoxamine, mexiletine, moricizine, other "adrenalin- like" drugs (e.g., ephedrine), digoxin, pentoxifylline, tacrine, dipyridamole injection, methotrexate, disulfiram, thiabendazole, zileuton, flu vaccine or ticlopidine, St John's wort. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include fast or irregular heartbeat, nausea or vomiting, unusual nervousness or restlessness, agitation, irritability, headache, and seizures.

NOTES: Do not share this medication with others. Laboratory and/or medical tests will be performed to monitor for side effects or response to treatment.

MISSED DOSE: If you miss a dose, contact your doctor or pharmacist promptly to establish a new dosing schedule.

STORAGE: Store the vials at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light. Do not freeze. Do not use after the expiration date. The drug mixed in IV fluids should be used within 48 hours.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

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Copyright 2004 by First DataBank, Inc.