IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

ARDEPARIN- INJECTION

(are-duh-PAIR-in)

COMMON BRAND NAME(S): Normiflo

WARNING: Tell your doctor you are using this medication before undergoing any procedure involving spinal puncture/anesthesia. Using this medication before these procedures has caused major bruising or bleeding (epidural or spinal hematoma) inside your body. This may leave you paralyzed, maybe permanently. Tell your doctor immediately if you have any of these serious side effects: tingling, weakness, numbness, difficulty urinating or pain. This risk is increased when you use other "blood thinning" medications (e.g., aspirin, clopidogrel, warfarin), NSAIDs (e.g., ibuprofen, naproxen), or when certain medication delivery devices (indwelling epidural catheters) are used. You will be monitored closely while you are on this medication.

USES: This medication is a "blood thinner" which helps prevent formation of blood clots. It is used after knee replacement surgery.

OTHER USES: This drug may also be used for other types of knee surgeries or to treat blood clots.

HOW TO USE: This medication is administered by injection under the skin (subcutaneously), by a health care professional usually twice a day following surgery. Injection sites will be rotated to limit irritation. Therapy with this medication may be continued for 7 to 14 days or until the risk of blood clot formation is limited. Do not inject into a muscle (intramuscularly). Properly discard used syringes and needles.

SIDE EFFECTS: Irritation, pain, tenderness and redness may occur at the site of injection. Nausea or swelling of the hands or feet may also occur. If these effects continue or become bothersome, inform your doctor. If you have had a spinal procedure along with this drug, promptly report weakness, numbness or pain. Notify your doctor if you experience: fever, mental confusion, unusual bruising or bleeding, black stools. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: liver problems, kidney problems, heart disease, eye problems, bleeding problems, blood disorders, stomach/intestinal problems, severe high blood pressure, stroke, eye/brain/spinal cord surgery, allergies (especially to drugs or pork). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all over-the-counter and prescription medication you may use, including: aspirin, warfarin, NSAID (e.g., ibuprofen, naproxen), other heparins. Because this drug can alter the effects of certain lab tests, be sure to remind your doctor you use this medication. This medication should not be mixed with, or added to, any other drug in the same syringe. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include excessive bleeding and bruising.

NOTES: Laboratory tests will be done periodically while taking this medication to monitor its effects and to prevent side effects.

MISSED DOSE: Use each dose at the scheduled time. If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

STORAGE: Store this medication at controlled room temperature 59 to 77 degrees F (15 to 25 degrees C). Do not freeze.

Developed by First DataBank, Inc., San Bruno, CA
Copyright 2004 by First DataBank, Inc.